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Major GEC ICI trials.
| Name of trial | Tumor subtype | Line of Rx | PD-L1 IHC selection | PD-L1 IHC stratification | References |
|---|---|---|---|---|---|
| ATTRACION-2 | GC | ≥3 | No | No | (35) |
| KEYNOTE-059 Cohort 1 |
GC | ≥3 | No | NA (non randomized) | (36) |
| JAVELIN-300 | GC | ≥3 | No | No | (23) |
| KEYNOTE-061 | GC | 2 | No (first 83%) CPS ≥ 1 (last 17%) |
Yes (CPS ≥ 1) | (25) |
| KEYNOTE-062 | GC | 1 | CPS ≥ 1 | No | (28) |
| JAVELIN-100 | GC | 1 | No | No | (28) |
| KEYNOTE-181 | EC | 2 | No | No | (15) |
| ATTRACTION-3 | ESCC | 2 | No | No | (41) |
| KEYNOTE-180 | EC | ≥3 | No | NA (non randomized) | (39) |
