Table 4.
Performance of metabolomics/lipidomics panels for groups discrimination.
| ROC analysis | Plasma metabolomics | Plasma lipidomics | Combined plasma metabolomics and lipidomics | |||
|---|---|---|---|---|---|---|
| Groups | Discovery group | Validation group | Discovery group | Validation group | Discovery group | Validation group |
| Cancer vs. Control | 0.985a | 0.944a | 0.993b | 0.976b | 1c | 0.99c |
| BC vs. RCC | 0.862d | 0.802d | 0.853e | 0.898e | 0.939f | 0.942f |
a
A panel consists of 9,10,13-TriHOME, 12,13-DHOME and linolenelaidic acid.
b
A panel consists of 11Z-Eicosenal, 6Z-Heneicosen-9-one, behenic acid and 7Z-Tricosen-11-one.
c
A panel consists of 9,10,13-TriHOME, 11Z-Eicosenal, 12,13-DHOME, 6Z-Heneicosen-9-one, linolenelaidic acid, behenic acid and 16-Hydroxy-10-oxohexadecanoic acid.
d
A panel consists of 7,8-Dihydropteroic acid, Avenoleic acid and 3,4-Dimethyl-5-pentyl-2-furanundecanoic acid.
e
A panel consists of PS(P-38:0), 4E,14Z-Sphingadiene and Tetrapedic acid A.
f
A panel consists of 7,8-Dihydropteroic acid, PS(P-38:0), 9,10,13-TriHOME, Avenoleic acid, 3,4-Dimethyl-5-pentyl-2-furanundecanoic acid and 4E,14Z-Sphingadiene.