Table 1. Characteristics, genotypes of EGF rs2237051 and serum EGF levels in GAgP patients and healthy controls.
| Risk of GAgP | GAgP patients | Healthy controls | P-value |
|---|---|---|---|
| N | 216 | 138 | |
| Age, years | 27.29 ± 4.25 | 27.10 ± 4.23 | 0.688 |
| Gender | 0.859 | ||
| Female | 85 (39.35%) | 53 (38.41%) | |
| Male | 131 (60.65%) | 85 (61.59%) | |
| BMI, Kg/m2 | 22.10 ± 3.52 | 21.28 ± 3.06 | 0.026* |
| BMI categories | 0.002* | ||
| <18.5 | 26 (12.32%) | 20 (14.60%) | |
| >=18.5, <24.9 | 138 (65.40%) | 106 (77.37%) | |
| >=24.9 | 47 (22.27%) | 11 (8.03%) | |
| Mean PLI | 2.34 ± 0.39 | 1.40 ± 0.46 | <0.001* |
| Mean PD, mm | 4.82 ± 0.98 | 1.89 ± 0.61 | <0.001* |
| Mean BI | 3.55 ± 0.47 | 1.17 ± 0.37 | <0.001* |
| Mean AL, mm | 4.29 ± 1.44 | 0.01 ± 0.52 | <0.001* |
| Serum EGF, pg/ml | 46.77 ± 9.38 | 33.54 ± 8.62 | <0.001* |
| Alleles of rs2237051 | 0.005* | ||
| A | 311 (71.99%) | 171 (61.96%) | |
| G | 121 (28.01%) | 105 (38.04%) | |
| Genotype of rs2237051 | 0.009* | ||
| GG | 12 (5.56%) | 19 (13.77%) | |
| AG | 97 (44.91%) | 67 (48.55%) | |
| AA | 107 (49.54%) | 52 (37.68%) | |
| Genotype of rs2237051 | 0.029* | ||
| AG/GG | 109 (50.46%) | 86 (62.32%) | |
| AA | 107 (49.54%) | 52 (37.68%) | |
| Genotype of rs2237051 | 0.008* | ||
| GG | 12 (5.56%) | 19 (13.77%) | |
| AG/AA | 204 (94.44%) | 119 (86.23%) |
Notes:
*
P < 0.05, statistical significance.
GAgP, generalized aggressive periodontitis; BMI, body mass index; PLI, plaque index; PD, probing depth; BI, bleeding index; AL, attachment loss; EGF, epidermal growth factor.
Results in table: Mean + SD/N (%).