Table III.
Diagnostic performance of mp-MRI to correctly identify EPE (prostatectomy specimens used as reference standard).
| Sensitivity, % (95%CI) | Specificity, % (95%CI) | PPV, % (95%CI) | NPV, % (95%CI) | AUCa (95%CI) | Accuracy rate, % | |
|---|---|---|---|---|---|---|
| Overall | ||||||
| Reader 1 | 76.5 (50.1; 93.2) | 66.7 (48.2; 82.0) | 54.2 (40.5; 67.2) | 84.6 (69.3; 93.1) | 0.716 (0.571; 0.834)b | 70.0 |
| Reader 2 | 94.1 (71.3; 99.9) | 84.9 (68.1; 94.9) | 76.2 (58.6; 87.9) | 96.6 (80.6; 99.5) | 0.895 (0.775; 0.964)b | 88.0 |
| Reader 3 | 82.4 (56.6; 96.2) | 45.5 (28.1; 63.6) | 43.8 (34.7; 53.2) | 83.3 (62.6; 93.7) | 0.639 (0.491; 0.770)b | 58.0 |
| mp-MRI performed after positive TRUS-guided prostate biopsy | ||||||
| Reader 1 | 60.0 (26.2; 87.8) | 57.7 (36.9; 76.6) | 35.3 (21.7; 51.8) | 78.9 (62.1; 89.6) | 0.588 (0.413; 0.749)c | 58.3 |
| Reader 2 | 90.0 (55.5; 99.7) | 80.8 (60.6; 93.4) | 64.3 (44.4; 80.3) | 95.5 (76.4; 99.3) | 0.854 (0.696; 0.949)c | 83.3 |
| Reader 3 | 70.0 (34.8; 93.3) | 42.3 (23.4; 63.1) | 31.8 (21.7; 44.0) | 78.6 (56.3; 91.3) | 0.562 (0.387; 0.726)c | 50.0 |
| mp-MRI performed before positive TRUS-guided prostate biopsy | ||||||
| Reader 1 | 100.0 (59.0; 100.0) | 100.0 (59.0; 100.0) | 100.0 | 100.0 | 1.000 (0.768; 1.000)d | 100.0 |
| Reader 2 | 100.0 (59.0; 100.0) | 100.0 (59.0; 100.0) | 100.0 | 100.0 | 1.000 (0.768; 1.000)d | 100.0 |
| Reader 3 | 100.0 (59.0; 100.0) | 57.14 (18.4; 90.1) | 70.0 (49.8; 84.6) | 100.0 | 0.786 (0.492; 0.953)d | 78.5 |
| mp-MRI with ERC | ||||||
| Reader 1 | 66.7 (29.9; 92.5) | 42.9 (17.7; 71.1) | 42.9 (28.2; 58.9) | 66.7 (39.9; 85.8) | 0.548 (0.329; 0.754)e | 52.2 |
| Reader 2 | 100.0 (66.4; 100.0) | 71.4 (41.9; 91.6) | 69.2 (49.6; 83.7) | 100.0 | 0.857 (0.649; 0.966)e | 82.6 |
| Reader 3 | 77.8 (40.0; 97.2) | 35.7 (12.8; 64.9) | 43.8 (31.5; 56.8) | 71.4 (37.9; 91.1) | 0.567 (0.347; 0.770)e | 52.2 |
| mp-MRI without ERC | ||||||
| Reader 1 | 87.5 (47.3; 99.7) | 84.2 (60.4; 96.6) | 70.0 (44.4; 87.2) | 94.1 (71.7; 99.0) | 0.859 (0.671; 0.962)f | 85.2 |
| Reader 2 | 85.7 (47.3; 99.7) | 94.7 (74.0; 99.9) | 87.5 (50.5; 98.0) | 94.7 (74.2; 99.1) | 0.911 (0.737; 0.986)f | 92.6 |
| Reader 3 | 87.5 (47.3; 99.7) | 52.6 (28.9; 75.6) | 43.8 (31.1; 57.2) | 90.9 (60.4; 98.5) | 0.701 (0495; 0.860)f | 63.0 |
mp-MRI = multiparametric MRI; TRUS = transrectal ultrasound; ERC = endorectal coil; PPV = positive predictive value; NPV = negative predictive value; CI = confidence interval; AUC = area under the receiver operating curve
p-values <0.05 for AUCs computed in the whole sample, for reader 2 in group with positive TRUS-guided biopsy performed before mp-MRI, for all readers in the group with positive TRUS-guided biopsy after mp-MRI, for reader 2 in group with ERC and for readers 1 and 2 in group without ERC
p-values for pairwise comparison between AUC for the 3 readers in the overall population: 0.001 for the comparison between reader 1 and reader 2; 0.259 for the comparison between reader 1 and reader 3; 0.001 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in the group with positive TRUS-guided biopsy performed before mp-MRI: 0.007 for the comparison between reader 1 and reader 2; 0.756 for the comparison between reader 1 and reader 3; 0.006 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in the group with positive TRUS-guided biopsy performed after mp-MRI: 1.000 for the comparison between readers 1 and reader 2; 0.102 for the comparison between reader 1 and reader 3; 0.102 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in group with ERC: 0.017 for the comparison between reader 1 and reader 2; 0.850 for the comparison between reader 1 and reader 3; 0.043 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in group without ERC: 0.394 for the comparison between readers 1 and reader 2; 0.043 for the comparison between reader 1 and reader 3; 0.017 for the comparison between reader 2 and reader 3.