Table IV.
Diagnostic performance of mp-MRI to correctly identify SVI (prostatectomy specimens used as reference standard).
| Sensitivity, % (95%CI) | Specificity, % (95%CI) | PPV, % (95%CI) | NPV, % (95%CI) | AUCa (95%CI) | Accuracy rate, % | |
|---|---|---|---|---|---|---|
| Overall | ||||||
| Reader 1 | 57.1 (18.4; 90.1) | 86.1 (72.1; 94.7) | 40.0 (20.0; 64.0) | 92.5 (83.9; 96.7) | 0.716 (0.571; 0.834)b | 82.0 |
| Reader 2 | 85.7 (42.1; 99.6) | 97.7 (87.7; 99.1) | 85.7 (45.8; 97.7) | 97.7 (87.2; 99.6) | 0.917 (0.804; 0.976)b | 96.0 |
| Reader 3 | 57.1 (18.4; 90.1) | 93.0 (80.9; 98.5) | 57.1 (27.3; 82.5) | 93.0 (85.0; 96.9) | 0.751 (0.608; 0.862)b | 88.0 |
| mp-MRI performed after positive TRUS-guided prostate biopsy | ||||||
| Reader 1 | 60.0 (14.7; 94.7) | 83.9 (66.3; 94.5) | 37.5 (17.0; 63.8) | 92.9 (81.5; 97.5) | 0.719 (0.545; 0.856)c | 80.5 |
| Reader 2 | 100.0 (47.8; 100.0) | 96.8 (83.3; 99.9) | 83.3 (42.1; 97.2) | 100.0 | 0.984 (0.874; 1.000)c | 97.2 |
| Reader 3 | 60.0 (14.7; 94.7) | 90.3 (74.2; 98.0) | 50.0 (21.6; 78.4) | 93.3 (82.6; 97.6) | 0.752 (0.580; 0.880)c | 86.1 |
| mp-MRI performed before positive TRUS-guided prostate biopsy | ||||||
| Reader 1 | 50.0 (1.3; 98.7) | 91.7 (61.5; 99.8) | 50.0 (8.8; 91.2) | 91.7 (73.1; 97.8) | 0.708 (0.413; 0.913)d | 85.7 |
| Reader 2 | 50.0 (1.3; 98.7) | 100.0 (73.5; 100.0) | 100.0 | 92.3 (75.0; 98.0) | 0.750 (0.455; 0.936)d | 92.8 |
| Reader 3 | 50.0 (1.3; 98.7) | 100.0 (73.5; 100.0) | 100.0 | 92.3 (75.0; 98.0) | 0.750 (0.455; 0.936)d | 92.8 |
| mp-MRI with ERC | ||||||
| Reader 1 | 66.7 (9.4; 99.2) | 70.0 (45.7; 88.1) | 25.0 (10.5; 48.6) | 93.3 (73.4; 98.6) | 0.683 (0.458; 0.859)e | 69.6 |
| Reader 2 | 100.0 (29.2; 100.0) | 95.0 (75.1; 99.9) | 75.0 (30.7; 95.3) | 100.0 | 0.975 (0.809; 1.000)e | 95.7 |
| Reader 3 | 33.3 (0.8; 90.6) | 85.0 (62.1; 96.8) | 25.0 (4.7; 69.2) | 89.5 (78.9; 95.1) | 0.592 (0.369; 0.789)e | 78.3 |
| mp-MRI without ERC | ||||||
| Reader 1 | 50.0 (6.8; 93.2) | 100.0 (85.2; 100.0) | 100.0 | 92.0 (81.2; 96.9) | 0.750 (0.547; 0.895)f | 92.6 |
| Reader 2 | 75.0 (19.4; 99.4) | 100.0 (85.2; 100.0) | 100.0 | 95.8 (80.8; 99.2) | 0.875 (0.691; 0.970)f | 96.3 |
| Reader 3 | 75.0 (19.4; 99.4) | 100.0 (85.2; 100.0) | 100.0 | 95.8 (80.8; 99.2) | 0.875 (0.691; 0.970)f | 96.3 |
mp-MRI = multiparametric MRI; TRUS = transrectal ultrasound; ERC = endorectal coil; PPV = positive predictive value; NPV = negative predictive value; CI = confidence interval; AUC = area under the receiver operating curve
p-values <0.05 for AUCs computed in the whole sample and for reader 2 in group with positive TRUS-guided biopsy performed before mp-MRI and in groups with and without ERC and for reader 3 in group without ERC
p-values for pairwise comparison between AUC for the 3 readers in the overall population: 0.082 for the comparison between reader 1 and reader 2; 0.767 for the comparison between reader 1 and reader 3; 0.128 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in the group with positive TRUS-guided biopsy performed before mp-MRI: 0.052 for the comparison between reader 1 and reader 2; 0.829 for the comparison between reader 1 and reader 3; 0.086 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in the group with positive TRUS-guided biopsy performed after mp-MRI: 0.865 for the comparison between Reader 1 and Reader 2; 0.865 for the comparison between Reader 1 and Reader 3; 1.000 for the comparison between Reader 2 and Reader 3
p-values for pairwise comparison between AUC for the 3 readers in group with ERC: 0.086 for the comparison between reader 1 and reader 2; 0.605 for the comparison between reader 1 and reader 3; 0.039 for the comparison between reader 2 and reader 3
p-values for pairwise comparison between AUC for the 3 readers in group without ERC: 0.499 for the comparison between reader 1 and reader 2; 0.499 for the comparison between reader 1 and reader 3; 1.000 for the comparison between reader 2 and reader 3.