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. 2020 May 19;11(20):1799–1815. doi: 10.18632/oncotarget.27546

Figure 5. Exposure to entinostat increases the expression of gene-sets involved in the effector functions of NK cells.

Figure 5

(A) Gene Set Enrichment Analysis (GSEA) results displayed according to the pathway with FDR, normalized enrichment score, and size of the gene set. Normalized enrichment score (NES) analyses revealed enrichment of gene-sets involved in cell adhesion, NK cell-mediated cellular cytotoxicity, IFN-γ-mediated signaling, and actin-cytoskeletal remodeling. Enrichment score were normalized to mean enrichment of random samples of the same size within the RNA-seq data. (B) Gene-set associated with NK cell adhesion are shown. Heatmap displaying genes with FDR < 0.05 associated with cell adhesion. (C) Heatmap displaying genes with FDR < 0.05 of NK Cell Cytotoxicity gene set. Gene-set associated with the cytotoxic functions of NK cells are shown. (D) Heatmap displaying genes with FDR < 0.05 of IFN-γ-mediated signaling-related gene set. Gene-set associated with IFN-γ-mediated signaling are shown. (E) Heatmap displaying genes with FDR < 0.05 of gene-set related to cytoskeletal reorganization. Gene-set associated with the actin-based cytoskeletal reorganization are shown. Data shown are obtained from RNA-Seq analyses of NK cells from three healthy donors with or without entinostat treatment.