Table 3. Relationships between baseline CSVD markers and change of cognitive function.

	Change of cognitive function
	MMSE		Memory		Language		Spatial construction		Attention		Executive function
	β	P	β	P	β	P	β	P	β	P	β	P
WMH volume, per 1% increase	-0.95	0.036	0.41	0.054	0.02	0.918	0.51	0.092	-0.07	0.770	-0.45	0.004
Lacunes, per No. increase	-0.56	0.123	-0.20	0.235	0.23	0.153	0.11	0.651	0.47	0.009	-0.04	0.734
CMBs, per No. increase	0.18	0.249	-0.03	0.643	-0.07	0.299	-0.12	0.261	-0.10	0.215	0.07	0.168
ePVS, per score increase	0.34	0.185	-0.21	0.092	0.17	0.134	-0.09	0.597	-0.06	0.642	-0.06	0.478

Adjusted for age, sex, interval, education years, ApoE ε4 carrier

Abbreviations: CSVD= cerebral small vessel disease; WMH = white matter hyperintensities; CMBs = cerebral microbleeds; ePVS = enlarged perivascular spaces; MMSE = Mini-Mental State Examination.