Table 1. Metformin management in patients with T2DM with stage 3A, 3B, and 4 CKD.
CKD stage | eGFR (mL·min-1·1.73 m-2) | Recommended daily dose |
3A | 45-59 | 0.5 g in the morning + 1 g in the evening |
3B | 30-44 | 0.5 g in the morning + 0.5 g in the evening |
4 | 15-29 | 500 mg in the morning |
T2DM: type 2 diabetes mellitus; CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate.