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. 2020 May 1;12(9):8742–8759. doi: 10.18632/aging.103095

Table 1. Metformin management in patients with T2DM with stage 3A, 3B, and 4 CKD.

CKD stage eGFR (mL·min-1·1.73 m-2) Recommended daily dose
3A 45-59 0.5 g in the morning + 1 g in the evening
3B 30-44 0.5 g in the morning + 0.5 g in the evening
4 15-29 500 mg in the morning

T2DM: type 2 diabetes mellitus; CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate.