Table 4. Univariable and multivariable linear mixed-effects model for the association of combined molecular groups with tumor growth rate.
| Molecular groups | No. | Univariable analysis | Multivariable analysis | |||||
| Interaction coefficients | SE | p | Interaction coefficients | SE | p | |||
| IDH1 + TERT +1p/19qa | ||||||||
| Triple-positive | 6 | reference | reference | |||||
| TERTmt and IDH1mt | 3 | 0.8 | 30.6 | 0.98 | 0.3 | 31.2 | 0.99 | |
| IDH1mt only | 5 | 32.0 | 27.7 | 0.3 | 27.0 | 30.6 | 0.4 | |
| TERTmt only | 12 | 73.0 | 23.2 | 0.002* | 64.4 | 26.4 | 0.02* | |
| Triple-negative | 12 | 18.5 | 22.8 | 0.4 | 17.7 | 25.4 | 0.5 | |
| IDH1 + MGMTb | ||||||||
| IDH1mt and MGMTmet | 14 | reference | reference | |||||
| IDH1mt/MGMTmet only | 14 | 29.4 | 18.0 | 0.1 | 34.3 | 19.7 | 0.08 | |
| IDH1 wt and non-MGMTmet | 9 | 61.0 | 20.9 | 0.004* | 57.8 | 21.2 | 0.01* | |
| IDH1 + ATRXc | ||||||||
| IDH1mt + ATRX low | 7 | reference | reference | |||||
| IDH1mt + ATRX high | 5 | -10.4 | 25.9 | 0.7 | -14.4 | 26.8 | 0.6 | |
| IDH1wt + ATRX low | 14 | 3.3 | 21.5 | 0.9 | -3.1 | 22.8 | 0.9 | |
| IDH1wt + ATRX high | 9 | 61.9 | 23.7 | 0.01* | 48.8 | 25.9 | 0.06 | |
Abbreviations: wt, wild type; mt, mutation type; met, methylation; SE, standard error.
a. After adjustment for WHO grade, ATRX, Ki67 and MGMT.
b. After adjustment for WHO grade, ATRX, Ki67 and TERT.
c. After adjustment for WHO grade, MGMT, Ki67 and TERT.
* p-value < 0.05 showed statistically significance.