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. 2020 May 9;12(9):8523–8535. doi: 10.18632/aging.103155

Table 2. Adsorption, distribution, metabolism, and excretion properties of compounds.

Number Compounds Solubility level BBB level CYP2D6 Hepatotoxicity Absorption level PPB level
1 ZINC000006094124 3 3 0 1 0 1
2 ZINC000014820552 2 2 0 1 0 1
3 ZINC000006092198 3 4 0 1 1 1
4 ZINC000018185774 4 3 0 1 0 0
5 ZINC000000899884 2 2 0 1 0 1
6 ZINC000018185774 3 4 1 1 0 0
7 ZINC000014820405 3 3 0 1 0 1
8 ZINC000020470300 2 1 0 1 0 1
9 ZINC000005732375 3 3 0 1 0 0
10 ZINC000028465419 2 2 0 1 0 0
11 ZINC000005732375 3 3 0 1 0 0
12 ZINC000006092239 3 3 0 1 0 1
13 ZINC000003871576 4 3 0 1 0 0
14 ZINC000013481874 4 4 0 1 0 0
15 ZINC000003871576 4 3 0 1 0 0
16 ZINC000000155807 3 4 0 1 0 0
17 ZINC000014820583 2 2 0 1 0 1
18 ZINC000005732375 3 3 0 1 0 1
19 ZINC000000895551 3 3 0 1 0 0
20 ZINC000018169010 4 4 0 1 3 0
21 ZINC000001532730 4 4 0 0 0 0

BBB, blood-brain barrier; CYP2D6, cytochrome P-450 2D6; PPB, plasma protein binding; O6-BG, O6-benzylguanine.

Aqueous-solubility level: 0, extremely low; 1, very low, but possible; 2, low; 3, good.

BBB level: 0, very high penetrant; 1, high; 2, medium; 3, low; 4, undefined.

CYP2D6 level: 0, noninhibitor; 1, inhibitor.

Hepatotoxicity: 0, nontoxic; 1, toxic.

Human-intestinal absorption level: 0, good; 1, moderate; 2, poor; 3, very poor.

PPB: 0, absorbent weak; 1, absorbent strong.