Table 2. Adsorption, distribution, metabolism, and excretion properties of compounds.

Number	Compounds	Solubility level	BBB level	CYP2D6	Hepatotoxicity	Absorption level	PPB level
1	ZINC000006094124	3	3	0	1	0	1
2	ZINC000014820552	2	2	0	1	0	1
3	ZINC000006092198	3	4	0	1	1	1
4	ZINC000018185774	4	3	0	1	0	0
5	ZINC000000899884	2	2	0	1	0	1
6	ZINC000018185774	3	4	1	1	0	0
7	ZINC000014820405	3	3	0	1	0	1
8	ZINC000020470300	2	1	0	1	0	1
9	ZINC000005732375	3	3	0	1	0	0
10	ZINC000028465419	2	2	0	1	0	0
11	ZINC000005732375	3	3	0	1	0	0
12	ZINC000006092239	3	3	0	1	0	1
13	ZINC000003871576	4	3	0	1	0	0
14	ZINC000013481874	4	4	0	1	0	0
15	ZINC000003871576	4	3	0	1	0	0
16	ZINC000000155807	3	4	0	1	0	0
17	ZINC000014820583	2	2	0	1	0	1
18	ZINC000005732375	3	3	0	1	0	1
19	ZINC000000895551	3	3	0	1	0	0
20	ZINC000018169010	4	4	0	1	3	0
21	ZINC000001532730	4	4	0	0	0	0

BBB, blood-brain barrier; CYP2D6, cytochrome P-450 2D6; PPB, plasma protein binding; O6-BG, O6-benzylguanine.

Aqueous-solubility level: 0, extremely low; 1, very low, but possible; 2, low; 3, good.

BBB level: 0, very high penetrant; 1, high; 2, medium; 3, low; 4, undefined.

CYP2D6 level: 0, noninhibitor; 1, inhibitor.

Hepatotoxicity: 0, nontoxic; 1, toxic.

Human-intestinal absorption level: 0, good; 1, moderate; 2, poor; 3, very poor.

PPB: 0, absorbent weak; 1, absorbent strong.