Figure 1.

Increased amplitude of mEPSCs in dissociated cultures of mouse cortical neurons after inhibition of action potentials for 48 h by treatment with 500 nm TTX. A, Phase contrast image of high-density cortical neuron culture with a pyramidal-shaped neuron chosen for recording. B, Representative example current traces of mEPSCs recorded in an untreated (CON) neuron and a TTX-treated (TTX) neuron. C, Average mEPSC current traces from the same recordings shown in B. D, Box and whisker plot of amplitude means for 86 untreated (14.0 ± 0.4 pA) and 77 TTX-treated neurons (17.5 ± 0.5 pA), from 23 cultures. p = 5.8 × 10⁻⁷, Kruskal–Wallis test. Box range, 25th–75th percentile; whisker, 10th–90th percentile; dot = mean; line = median.