Table 3.
Comparison of no treatment failure and treatment failure (by Day 3) by Baseline Characteristics of Patients Completed per Protocol Treatment (n=3856)
| No treatment failure | Treatment failure | OR (95% CI) | P value | |
|---|---|---|---|---|
| Treatment | ||||
| Amoxicillin | 1878/3710(50.6) | 51/146(34.9) | Reference | |
| Placebo | 1832/3710(49.4) | 95/146(65.1) | 1.9(1.4-2.7) | <0.001 |
| Demographic Indicators | ||||
| Sex | ||||
| Male | 1948/3710(52.5) | 82/146(56.2) | 1.2 (0.8-1.6) | 0.39 |
| Age categories in month | ||||
| 2-11 | 1707/3710(46.0) | 70/146(48.0) | Reference | |
| 12-59 | 2003/3710(54.0) | 76/146(52.1) | 1.1 (0.8-1.5) | 0.65 |
| Maternal years of schooling | ||||
| No education | 2329/3710(62.8) | 88/146(60.3) | 0.9 (0.3-2.2) | 0.75 |
| 1-5 years | 521/3710(14.0) | 22/146(15.1) | 1.0 (0.4-2.6) | 0.94 |
| 6-10 years | 746/3710(20.1) | 31/146(21.2) | 0.9 (0.4-2.5) | 0.91 |
| Above 10 years | 114/3710(3.1) | 5/146(3.4) | Reference | |
| Reported symptoms of | ||||
| Diarrhea | 280/3710(7.6) | 19/146(13.0) | 1.8 (1.1-3.0) | 0.02 |
| Fever | 2164/3710(58.3) | 110/146(75.3) | 2.2 (1.5-3.2) | <0.001 |
| Cough | 3683/3710(99.3) | 145/146(99.3) | 1.1 (0.1-7.9) | 0.95 |
| Fast/difficult breathing | 2387/3710(64.3) | 104/146(71.2) | 1.4 (1.0-2.0) | 0.09 |
| Chest in-drawing | 47/3710(1.3) | 2/146(1.4) | 1.1 (0.3-4.5) | 0.91 |
| URTI | 1397/3710(37.7) | 55/146(37.7) | 1.0 (0.7-1.4) | 0.99 |
| Vomiting | 63/3710(1.7) | 3/146(2.1) | 1.2 (0.4-3.9) | 0.75 |
| Measles(within last 3 month) | 26/3710(0.7) | 1/146(0.7) | 1.0 (0.1-7.3) | 0.98 |
| Breastfeeding with age categories | ||||
| 2-5 month | 1023/1069(95.7) | 44/44(100.0) | -- | -- |
| 6-11 month | 616/637(96.7) | 22/26(84.6) | 0.2 (0.1-0.6) | 0.004 |
| 12-24 month | 956/1007(94.9) | 44/45(97.8) | 2.3 (0.3- | 0.40 |
| Immunization a | ||||
| Up to date immunization | 1838/3710(49.5) | 61/146(41.8) | 0.7 (0.5-1.0) | 0.07 |
| Up to date PCV and Pentavalent | 2293/3710(61.8) | 89/146(61.0) | 1.0 (0.7-1.4) | 0.84 |
| Physical Examination | ||||
| Anemia | 369/3710(10.0) | 23/146(15.8) | 1.7 (1.1-2.7) | 0.02 |
| MUAC <11.5 cm b | 80/2641(3.0) | 4/102(3.9) | 1.3 (0.5-3.6) | 0.61 |
| Stunting(HAZ<-2 SD) | 1687/3684(45.8) | 71/144(49.3) | 1.2 (0.8-1.6) | 0.41 |
| Wasting(WHZ<-2SD) | 664/3673(18.1) | 30/142(21.1) | 1.2 (0.8-1.8) | 0.36 |
| Under-weight(WAZ<-2SD) | 1543/3703(41.7) | 67/145(46.2) | 1.2 (0.9-1.7) | 0.28 |
| Temperature ≥37.5 °C | 1175/3710(31.7) | 74/146(50.7) | 2.2 (1.6-3.1) | <0.001 |
| RR child | ||||
| 40-49 | 1620/2003(80.9) | 53/76(69.7) | Ref. | |
| 50-59 | 334/2003(16.7) | 19/76(25.0) | 1.7 (1.0-3.0) | 0.04 |
| 60-69 | 44/2003(2.2) | 3/76(4.0) | 2.1 (0.6-6.9) | 0.23 |
| ≥70 | 5/2003(0.3) | 1/76(1.3) | 6.1 (0.7- | 0.10 |
| RR Infant | ||||
| 50-59 | 1463/1707(85.7) | 51/70(72.9) | Reference | |
| 60-69 | 221/1707(13.0) | 15/70(21.4) | 1.9 (1.1-3.5) | 0.04 |
| 70-79 | 20/1707(1.2) | 3/70(4.3) | 4.3 (1.2- | 0.02 |
| ≥80 | 3/1707(0.2) | 1/70(1.4) | 9.6 (1.0- | 0.05 |
| Oxygen Saturation | ||||
| 90-92 | 467/3710(12.6) | 23/146(15.8) | Reference | |
| 93-95 | 990/3710(26.7) | 44/146(30.1) | 0.9 (0.5-1.5) | 0.69 |
| >95 | 2253/3710(60.7) | 79/146(54.1) | 0.7 (0.4-1.1) | 0.16 |
| Wheeze | 261/3710(7.0) | 19/146(13.0) | 2.0 (1.2-3.3) | 0.007 |
| Household demographics | ||||
| HH with Improved drinking waterc | 3388/3710(91.3) | 130/146(89.0) | 0.8 (0.5-1.3) | 0.34 |
| HH with Improved sanitationd | 3406/3710(91.8) | 137/146(93.8) | 1.4 (0.7-2.7) | 0.38 |
| HH indoor air qualitye | ||||
| Adequate | 1991/3710(53.7) | 61/146(41.8) | Reference | |
| Inadequate | 1719/3710(46.3) | 85/146(58.2) | 1.6 (1.2-2.2) | 0.005 |
Data reported as n/N(%)
Children received age appropriate vaccines doses as per the standard immunization schedule
MUAC (Mid Upper Arm Circumference) not applicable for children under 6 month of age
HH (Household) with Improved drinking water includes piped water, tube well and bottled water
HH with Improved sanitation facilities included septic tanks and pit latrine
Indoor air quality index were created from 6 air quality variables includes HH have proper ventilation, smoking inside house, source of fuel wood ,charcoal or animal dung, cooking place , stove type, presence of child near cooking area using Principal Component Analysis. Quartiles were created from PCA score to group sampled population into three categories. A binary variable further created combining lower two quartiles reflecting inadequate air quality.
WAZ-Weight for age Z score, HAZ-Height for age Z score, WHZ-Weight for height Z score