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. 2020 May 18;13:4339–4348. doi: 10.2147/OTT.S249895

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© 2020 Bai and Chen.

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Five selected genes levels are correlated with poor survival in newly diagnosed myeloma patients. (A–E) Gene expression of NP (n = 22), MGUS (n = 44), SMM (n = 12) and MM (n = 559) in GSE5900 and GSE2658 datasets (upper row). Kaplan–Meier analysis on the overall survival of MM patients in TT2 cohorts based on the gene expression (lower row). (F) 5 selected gene mRNA expression from MM patients with paired SP/LC and CD138⁺ MM cells were detected by qRT-PCR. (G) The protein network was constructed by online STRING software.

Abbreviations: NP, normal plasma; MGUS, monoclonal gammopathy of undetermined significance; SMM, smoldering multiple myeloma; qRT-PCR, quantitative real-time PCR; TT2. Total therapy 2.