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. 2020 May 18;13:4305–4318. doi: 10.2147/OTT.S242854

Figure 2.

Figure 2

The high expression of LINC01614 in glioma was induced by SP1. (A) The methylation levels of LINC01614 promoter region in tumor specimens of diverse cancer types were analyzed by using LncBook algorithm. (B) JASPAR dataset predicted SP1-binding sites in LINC01614 promoter. (C) qPCR examined the expression of SP1. (D) qPCR determined LINC01614 levels in glioma cells after transfection with si-SP1 or ov-SP1. (E) ChIP assays were employed for analyzing the SP1-binding sites. (F) Luciferase reporter assays. **P < 0.01. n.s (not significant) represents “P > 0.05”.