Table 1. Reaction intensification using cyclohexane cosolvent.
Conversions to 6 obtained in the reductive amination of cyclohexanone with aniline at different substrate and cosolvent loadings, as determined by GC-FID. All reactions contained 500 μl of aqueous components and variable total volumes from 700 to 900 μl.
| Entry | [Cyclohexanone] (mM) | [Aniline] (mM) | Cyclohexane (μl) | Conversion to 6 (%) |
| 1 | 50 | 100 | 200 | 81 |
| 2 | 50 | 100 | 250 | 75 |
| 3 | 50 | 100 | 300 | 76 |
| 4 | 75 | 100 | 300 | 74 |
| 5 | 100 | 100 | 300 | 59 |
| 6 | 50 | 100 | 350 | 75 |
| 7 | 50 | 100 | 400 | 71 |