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. Author manuscript; available in PMC: 2021 Apr 21.
Published in final edited form as: Acc Chem Res. 2020 Mar 23;53(4):949–961. doi: 10.1021/acs.accounts.0c00055

Figure 4.

Figure 4.

Representative ophiobolin sesterterpene (–)-6-epi-ophiobolin N (3). (A) Cyclase-mediated construction of the ophiobolin 5,8,5-fused ring system (B) Isoprenoid building block-based disconnection.