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. 2020 May 18;14:1897–1908. doi: 10.2147/DDDT.S252626

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© 2020 Cheng et al.

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Leflunomide inhibited PI3K/Akt signaling pathway in bladder cancer cells. 5637 and T24 cells were treated with leflunomide (200μM) or DMSO for 6 to 48 hours, the phosphorylation levels of PI3K/Akt pathway proteins in 5637 (A and B) and T24 (C and D) cells were determined by Western blot. The results (B and D) represent the mean ± SD from three independent experiments. *P<0.05; **P<0.01.