Table 1.
Participant demographics
| THC (n = 35) | PBO (n = 36) | p-value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| PTSD (n = 10) | TEC (n = 13) | HC (n = 12) | Total | PTSD (n = 9) | TEC (n = 14) | HC (n = 13) | Total | ||
| Age (mean years, SD) | 26.00 (5.46) | 28.31 (7.42) | 24.33 (2.53) | 26.29 (5.69) | 23.33 (3.08) | 26.43 (7.08) | 26.85 (6.66) | 25.81 (6.17) | 0.852 |
| Gender (n, female) | 9 | 5 | 5 | 19 | 5 | 8 | 4 | 17 | 0.552 |
| Race (n) | 0.803 | ||||||||
| African American | 2 | 4 | 0 | 6 | 1 | 3 | 2 | 6 | |
| Asian | 1 | 3 | 5 | 9 | 1 | 4 | 4 | 9 | |
| American Indian/ Alaskan Native | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Caucasian | 6 | 5 | 7 | 18 | 6 | 5 | 7 | 18 | |
| More than one race | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | |
| Other | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | |
| Hispanic or Latino (n) | 1 | 1 | 0 | 2 | 0 | 1 | 2 | 3 | 0.468 |
| PTSD severity (CAPS-5) | |||||||||
| Total severity score (mean, SD) | 33.60 (10.95) | 2.69 (5.15) | -- | 11.60 (15.76) | 34.11 (6.83) | 4.00 (6.08) | -- | 11.11 (15.15) | 0.993 |
| Number of clinically significant symptoms (mean, SD) | 11.20 (2.57) | 0.92 (2.29) | -- | 3.83 (5.19) | 12.33 (2.87) | 1.14 (2.03) | -- | 3.83 (5.60) | 0.618 |
| Cannabis Use | |||||||||
| Used in the past 30 days (n) | 3 | 3 | 1 | 7 | 2 | 1 | 0 | 3 | 0.189 |
| Occasions (mean, SD) | 2.00 (1.00) | 1.00 (1.00) | 10.00 (0.00) | 3.00 (3.21) | 17.00 (18.00) | 1.00 (0.00) | -- | 11.67 (15.95) | 0.446 |
| Occasions lifetime (n) | 0.288 | ||||||||
| Never | 1 | 5 | 7 | 13 | 4 | 5 | 7 | 16 | |
| 1–10 | 1 | 4 | 2 | 7 | 1 | 4 | 4 | 9 | |
| 11–50 | 6 | 1 | 1 | 8 | 2 | 5 | 1 | 8 | |
| 51–100 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | |
| < 100 | 2 | 1 | 2 | 5 | 2 | 0 | 1 | 3 | |
Abbreviations: THC, Δ9-tetrahydrocannabinol; PBO, placebo; PTSD, posttraumatic stress disorder; TEC, trauma-exposed control; HC, healthy control; CAPS-5, Clinician-Administered PTSD Scale for DSM-5. Items in BOLD, either refer to the highest category of demographics (age, gender, race, ethnicity, PTSD severity, or cannabis use) or the total number of participants/mean age across the three subgroups (PTSD/TEC/HC). Reported p-values are between-drug group comparisons.