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. Author manuscript; available in PMC: 2021 May 20.
Published in final edited form as: Neuron. 2020 Mar 19;106(4):649–661.e4. doi: 10.1016/j.neuron.2020.02.030

Figure 3: M1R blockade reduces delay-related firing and spatial tuning of dlPFC Delay cells.

Figure 3:

A. Iontophoresis of the M1R antagonist, telen, markedly reduced delay firing, and firing was partially restored when telen application was terminated (recovery). B. Telen reduces delay-related firing and spatial tuning at the population level. Upper panel shows normalized average firing rates for 29 Delay cells. Bottom left shows the mean±SEM firing rate of 29 Delay cells during the Delay period of the task. Bottom right shows iontophoresis of telen significantly decreased the spatial tuning of Delay cells by decreasing d’. C. Piren reduces delay firing and spatial tuning at the population level. (*p<0.05; **p<0.01, ***p<0.001).