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. Author manuscript; available in PMC: 2021 May 20.
Published in final edited form as: Neuron. 2020 Mar 19;106(4):649–661.e4. doi: 10.1016/j.neuron.2020.02.030

Figure 8. Opening KCNQ channels blocks the enhancement from M1R stimulation and closing KCNQ channels rescues the reduction from M1R blockade.

Figure 8.

A. VU035 significantly enhanced delay firing, and retigabine blocked this enhancement when these two agents were co-applied. B. Retigabine significantly blocked the enhancement of VU035 at the population level. C. Retigabine blocked the enhancement of VU035 on spatial tuning. D. Telen dramatically reduced delay-related firing, and XE991 rescued the reduction of telen when these two agents were co-applied. E. XE991 significantly rescued the reduction of telen at the population level. F. XE991 rescued the reduction of telen on spatial tuning. (*p<0.05; **p<0.01, ***p<0.001; Data are represented as mean±SEM).