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Acute amitifadine interaction with remifentanil hot plate response (mean ± sem), N = 12. Amitifadine did not attenuate the analgesic effect of remifentanil, but rather caused antinociception on its own that outlasted the analgesic effect of remifentanil. There was no evidence that the combination of remifentanil and amitifadine treatment had a significant effect on the antinociceptive effect of the other drug.
