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. 2019 Aug 22;25(6):1159–1174. doi: 10.1038/s41380-019-0493-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Analysis of differentially expressed genes in the medial prefrontal cortex (mPFC) of P15 animals exposed to maternal separation highlights myelin ensheathment and immediate early genes. a Schematic presentation of the experimental paradigm of the maternal separation (MS pups) versus standard facility (SFR pups) protocols and the dissection of mPFC at P15 to generate four samples per condition, each including three unilateral mPFC. b Graph shows with a log2 scale the fold change (FC) of expression induced by maternal separation according to the number of reads detected in control samples for the genes with q < 0.05 and FC > 1.3 or FC < 0.7. Myelin-ensheathment genes are highlighted in red, and immediate early genes in blue. c, d Graphs show the quantitative PCR (qPCR) results obtained in a second experimental cohort to determine the expression levels of IEG (C, n = 7 SFR animals and n = 6 MS) and genes related to myelin ensheathment (D, n = 6 SFR animals and 9 MS). *p < 0.05, **p < 0.01