Table 1.

Examples of viral infections for which chloroquine or hydroxychloroquine have been tested in vitro and in clinical trials.

Infection	Drug tested	In vitro Activity	Efficacy in clinical trials
HIV	Hydroxychloroquine	Inhibits the replication of HIV	Decreased CD4 and increased viral load
Dengue	Chloroquine	Inhibits the replication of the virus	No clinical efficacy demonstrated
Chikungunya	Chloroquine	Inhibits the replication of the virus	No effect on viral load; increase in arthralgia
Influenza	Chloroquine (prophylactic)	Inhibits the replication of H1N1 and H3N2 viruses	No prevention of influenza; more adverse events in the chloroquine group
Hepatitis C	Chloroquine	Inhibits the replication of HCV	Decreased viral load; this effect ceased on stopping chloroquine