Table 2.
Vital signs and gas exchange parameters at different time-points after study drugs administration in treated patients (n = 5) and compared with matched controls. Data are expressed as means (standard deviation). Within – P(1) - and between - P(2) – group difference is reported. Statistically significant differences are in bold. Resp. rate: respiratory rate; bpm: breaths per minute; ASBP: arterial systolic blood pressure; HR: heart rate. For other abbreviations please see Table 1 and main text.
| Group | Baseline | 24 h | 48 h | 7 d | P (1) | P (2) | |
|---|---|---|---|---|---|---|---|
| Vital signs | |||||||
| Resp. rate, bpm | Treated | 27 (6) | 26 (6) | 25 (5) | 22 (6) | 0.049 | 0.127 |
| Control | 28 (5) | 27 (5) | 25 (5) | 25 (6) | 0.051 | ||
| ASBP, mmHg | Treated | 105 (22) | 110 (20) | 112 (18) | 120 (20) | 0.168 | 0.638 |
| Control | 125 (30) | 130 (28) | 120 (26) | 115 (34) | 0.237 | ||
| HR, beats/min | Treated | 94 (10) | 90 (8) | 96 (10) | 88 (7) | 0.069 | 0.142 |
| Control | 96 (12) | 94 (15) | 90 (11) | 92 (14) | 0.146 | ||
| Gas exchange | |||||||
| pH | Treated | 7.48 (0.04) | 7.47 (0.04) | 7.44 (0.03) | 7.47 (0.07) | 0.309 | 0.959 |
| Control | 7.48 (0.05) | 7.48 (0.04) | 7.46 (0.03) | 7.49 (0.01) | 0.406 | ||
| PaO2, mmHg | Treated | 73 (18.9) | 102 (44.7) | 106 (34.2) | 95 (32.6) | 0.693 | 0.875 |
| Control | 97 (37) | 90 (19) | 98 (22) | 78 (16) | 0.455 | ||
| PaCO2, mmHg | Treated | 39 (4.9) | 43 (3.4) | 44 (4.2) | 41 (4.2) | 0.144 | 0.852 |
| Control | 39 (7.2) | 43 (7.3) | 42 (6.4) | 42 (9.0) | 0.274 | ||
| PaO2/FiO2, mmHg | Treated | 146 (42.4) | 198 (56.9) | 210 (43.5) | 258 (62.3) | 0.037 | 0.207 |
| Control | 161 (6.2) | 139 (43) | 166 (45) | 181 (78) | 0.283 | ||
| A-a O2, mmHg | Treated | 248 (69.6) | 216 (54.4) | 196 (54.4) | 97 (48.0) | 0.005 | 0.047 |
| Control | 282 (36) | 354 (122) | 292 (130) | 226 (92) | 0.305 | ||
| SaO2, % | Treated | 94 (3) | 96 (4) | 98 (2) | 97 (2) | 0.220 | 0.553 |
| Control | 96 (4) | 98 (2) | 98 (1) | 96 (4) | 0.521 | ||
| HCO3-, mmol/L | Treated | 29.9 (3.0) | 30 (3.6) | 28.8 (2.8) | 29.5 (5.7) | 0.186 | 0.939 |
| Control | 28.2 (5.2) | 29.8 (2.7) | 29.4 (3.2) | 30.3 (4.8) | 0.738 | ||
| Lactates, mmol/L | Treated | 1.4 (0.6) | 1.4 (0.9) | 1.3 (0.8) | 1.0 (0.5) | 0.487 | 0.029 |
| Control | 1.6 (0.9) | 1.3 (0.3) | 1.8 (1.1) | 2.1 (0.4) | 0.439 |