Table 3.
Blood count parameters at different time-points after study drugs administration in treated patients (n = 5) and compared with matched controls. Data are expressed as means (standard deviation). Within – P(1) - and between - P(2) – group difference is reported. Statistically significant differences are in bold. For abbreviations please see Table 1 and main text.
| Group | Baseline | 24 h | 48 h | 7 d | P (1) | P (2) | |
|---|---|---|---|---|---|---|---|
|
Blood count/ biochemistry |
|||||||
| WBC, x109/L | Treated | 10616 (3478) | 10700 (4247) | 11924 (5889) | 8570 (1727) | 0.242 | 0.685 |
| Control | 10454 (4589) | 6990 (2096) | 10915 (4314) | 9888 (4223) | 0.508 | ||
| Neutrophils, x109/L | Treated | 8500 (3230) | 8356 (4581) | 9880 (7424) | 6094 (2100) | 0.301 | 0.869 |
| Control | 9176 (4681) | 6085 (2177) | 10530 (3761) | 8524 (4350) | 0.630 | ||
| Lymphocytes, x109/L | Treated | 1208 (480) | 1328 (540) | 1380 (698) | 1422 (302) | 0.833 | 0.021 |
| Control | 730 (209) | 678 (319) | 468 (187) | 778 (525) | 0.179 | ||
| PLT, x1012/L | Treated | 253 (113) | 276 (130) | 305 (141) | 215 (121) | 0.147 | 0.377 |
| Control | 251 (130) | 237 (133) | 199 (96) | 246 (107) | 0.573 | ||
| Hb, g/L | Treated | 11.88 (1.4) | 11.9 (1.4) | 11.9 (5.6) | 11.5 (5.6) | 0.136 | 0.695 |
| Control | 12.7 (1.0) | 12.0 (1.2) | 10.8 (1.7) | 10.9 (2.0) | 0.112 | ||
| Ht, L/L | Treated | 35.2 (4.3) | 35.4 (4.0) | 35.5 (5.9) | 33.6 (6.5) | 0.761 | 0.785 |
| Control | 36 (4) | 36 (5) | 34 (7) | 31 (6) | 0.045 | ||
| D-dimer, μg/L FEU | Treated | 3038 (995) | 5309 (5309) | 5229 (6637) | 2202 (1191) | 0.577 | 0.749 |
| Control | 4038 (1301) | 4562 (2348) | 5324 (5537) | 4669 (5140) | 0.678 | ||
| Fibrinogen, g/L | Treated | 5.6 (1.3) | 5.6 (1.3) | 5.8 (1.2) | 5.7 (2.7) | 0.724 | 0.206 |
| Control | 6.2 (0.8) | 6.0 (1.4) | 4.3 (1.2) | 4.5 (1.7) | 0.329 | ||
| PT, s | Treated | 14 (1.3) | 13 (1.3) | 14 (2.5) | 13 (5.8) | 0.366 | 0.700 |
| Control | 14.6 (1.5) | 13.6 (1.4) | 14.4 (1.3) | 14.0 (1.2) | 0.859 | ||
| PTT, s | Treated | 30 (4.1) | 30 (8.6) | 33 (7.1) | 34 (8.6) | 0.179 | 0.827 |
| Control | 33 (5) | 31 (3) | 30 (5) | 32 (3) | 0.590 | ||
| LDH, U/L | Treated | 402 (211) | 447 (186) | 432 (226) | 337 (103) | 0.344 | 0.082 |
| Control | 591 (291) | 549 (199) | 571 (423) | 438 (247) | 0.610 | ||
| Creatinine, mg/dL | Treated | 0.68 (0.27) | 0.72 (0.39) | 0.70 (0.35) | 0.84 (0.54) | 0.190 | 0.757 |
| Control | 0.84 (0.22) | 0.81 (0.26) | 0.87 (0.49) | 0.80 (0.45) | 0.625 | ||
| BUN, mg/dL | Treated | 36 (7.6) | 30 (5.2) | 33 (10.5) | 36 (17.6) | 0.702 | 0.228 |
| Control | 41 (14) | 39 (18) | 48 (26) | 34 (19) | 0.650 | ||
| CRP, mg/L | Treated | 62 (45.5) | 55 (41.8) | 57 (54.0) | 28 (34.1) | 0.044 | 0.291 |
| Control | 150 (117) | 68 (87) | 71 (45) | 41 (57) | 0.380 |