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. 2020 Feb 21;58(3):377–387. doi: 10.1007/s12016-020-08779-5

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© The Author(s) 2020

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Fig. 1 — Tissue-resident MCs are the terminally differentiated cells from CD34+/CD117+ MC progenitors (MCps) that originate from the bone marrow. MCps after being released into the circulation reach their target tissues according to a controlled trafficking pattern mostly based on ligand-integrin interactions enter the tissues. MC expression of α4β7 and α4β1 integrins by MCps with vascular cell adhesion molecule (VCAM)-1 expressed by the endothelium of lung tissues, for example, supports their trafficking into the lungs. MCp differentiation to functional and mature MCs depends on several growth factors including stem cell factor (SCF), interleukin (IL)-3, IL-4, IL-9, IL-33, nerve growth factor (NGF), and transforming growth factor (TGF)-β