Table 1.

Previous human studies aimed to determine the role of MCs in shaping TME

Type/site of the tumor	Comments	Ref
Non-small cell lung cancer (NSCLC)	MCs were accumulated in tumors, and both MCT and MCTC were abundant in tumors of patients with extended survival.	[13]
Hodgkin’s lymphoma	Higher rates of MC infiltration in tumors were related to a worse relapse-free survival of patients.	[14]
Colorectal cancer	Infiltration of tryptase-positive MCs is an oncogenic event in colorectal cancer with poor prognosis. Tryptase activates PAR-2 receptor which activation promotes the progression of colorectal cancer.	[15]
Oral squamous cell carcinoma (OSCC)	A significantly higher MC density was observed in lesions compared with control. The presence of MCs in tumors was associated with a better prognosis.	[16]
Breast cancer	The number of tryptase+ MCs in tumors was significantly higher than that of peritumoral and non-tumoral controls	[17, 18]
Prostate cancer	Intratumoral MCs were found protective against prostate cancer recurrence.	[10]
	CD117+ MCs showed a denser accumulation in prostate adenocarcinoma (PCa) in comparison with benign prostate tissues that were correlated with the levels of serum prostate-specific antigen (sPSA) and the tumor progression and aggressiveness.	[19]
Cutaneous T cell lymphomas (CTCL)	Infiltration and accumulation of MCs were observed in different rates around CTCL. They accumulate mostly in the area immediately around the tumor.	[20]
Clear-cell renal cell carcinoma (ccRCC)	Infiltrated MC density was negatively correlated with the size of the tumor and reported as a predictor of cancer-specific survival and relapse-free survival in nonmetastatic ccRCC.	[11]
Gastric cancer (GC)	MC density was increased in well-differentiated GC.	[21]
	Tryptase-positive MCs have a role in angiogenesis in the primary tumor and in LNs of patients with metastatic GC.	[22]
Endometrial carcinoma	An increased number of MCs were observed in different stages in which grade III showed the highest MC accumulation. Tryptase-positive MC accumulation was in correlation with angiogenesis and tumor progression.	[23]
Renal cell carcinoma (RCC)	MC infiltration was correlated with angiogenesis and the progression of tumors	[24, 25]
Pancreatic cancer	Increased level of MC-released tryptase in plasma and TME correlates with tumor angiogenesis.	[26]
Thyroid carcinoma	MCD was significantly increased in tumors. Higher rate of MC infiltration was correlated with extrathyroidal extension	[27]
Renal cancer	An inverse correlation was found between the count of accumulated MCs in the peritumorous region and 5-year postoperative patient survival. MCD had a correlation with the tumor size and angiogenesis within peritumorous zone.	[28]