Table 3.
Correlations between surrogate endpoints and OS in patients with osteosarcoma.
| Surrogate endpoint | R2 (95% CI) | ρ (95% CI) | P-value for ρ | No. of studies |
|---|---|---|---|---|
| EFS | 0.456 (0.112–0.799) | 0.440 (−0.147, 0.797) | 0.1329 | 13 |
| 1-year EFS | 0.088 (0.00–0.341) | 0.049 (−0.516, 0.585) | 0.8725 | 13 |
| 3-year EFS | 0.279 (0.00–0.634) | 0.484 (−0.092, 0.817) | 0.0941 | 13 |
| 5-year EFS | 0.530 (0.210–0.850) | 0.564 (0.019, 0.851) | 0.0447 | 13 |
| 1-year OS | 0.406 (0.052–0.759) | 0.564 (0.019, 0.851) | 0.0447 | 13 |
| 3-year OS | 0.647 (0.382–0.912) | 0.758 (0.355, 0.923) | 0.0027 | 13 |
| 5-year OS | 0.745 (0.540–0.951) | 0.841 (0.540, 0.951) | 0.0003 | 13 |
| RR | 0.242 (0.00–0.709) | −0.464 (−0.927, 0.558) | 0.3542 | 6 |
Abbreviations: CI, confidence interval; EFS, event-free survival; OS, overall survival; RR, response rate.