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. 2020 May 22;3:259. doi: 10.1038/s42003-020-0985-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a StepMiner analysis was used to identify distinct Boolean patterns of gene expression in patient macrophages over the first 21 days of life. Each point represents a distinct control (not LPS treated) patient sample. Analysis results shown for normalized expression of genes representative of distinct patterns in severe BPD patients. b and c Heat map analysis of the genes displaying time-dependent changes in patients with severe BPD (b) or patients with none or mild BPD (c). d To illustrate the unique temporal pattern of expression in patients with no BPD or mild BPD, expression of genes from c were plotted for patients with severe BPD. e Venn diagram showing that only 100 genes out of 3654 identified in patients with none or mild BPD also had time dependent expression changes in severe BPD patients. f Reactome analysis of time-dependent genes from b, c. g, h Transcription factor motif analysis of genes enriched in patients with none/mild BPD compared to patients with severe BPD. Gene lists generated from StepMiner analysis of control samples from patients with none/mild BPD (g) and severe BPD (h) were analyzed for over represented motifs using oPOSSUM 3.0. Top six motifs based on Fisher score are shown for each group along with graphical representation of their consensus motif. (For severe BPD, n = 25 on day 1, n = 14 on day 7, n = 9 on day 14, n = 4 on day 21; for none/mild BPD, n = 13 on day 1, n = 5 on day 7, n = 4 on day 14, n = 3 on day 21).