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. 2020 May 22;10:8570. doi: 10.1038/s41598-020-65382-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of three minutes of acute nicotine exposure on locomotion and anxiety. Acute exposure to 25, 50, 100, or 400 mg/L did not have a significant effect on distance moved (A). Administration of 50 mg/L of nicotine significantly increased time spent immobile (B). No effect was found for the time spent in the inner zone (C), however, acute exposure to 100 and 400 mg/L of nicotine significantly increased time spent in the transition zone (D). Time in the thigmotaxis zone was decreased by 100 and 400 mg/L of nicotine (E). ****P < 0.0001; *P < 0.05.