Fig. 1. Pathophysiological implication of metabolite release by apoptotic cells on tissue dynamics.

Apopotic cells display active polyamine biogenesis and influence the behavior of neighbors live cells through the PANX1-dependent secretion of a combination of metabolites. The biological effects of the apoptotic secretome (that could be modulated upstream by strategies targeting metabolic circuitries or cellular responses to stress) may be harnessed to improve tissue response to damage and anti-cancer immunosruveillance.