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. 2020 May 22;11:2595. doi: 10.1038/s41467-020-16089-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b The comparisons between left SD (n = 28) vs. controls (n = 20) and right SD (n = 19) vs. controls. The two-sided voxel-based independent t-tests were used (df = 46 and 37, respectively; FDR-corrected p < 0.05). c the comparison between left and right SD. The two-sided voxel-based independent t-test was used (df = 45; FDR-corrected p < 0.05). d the ROIs used in the multiple regression analyses. e Scatterplots showing the distribution and inter-relationships of left ATL, right ATL and OFC atrophy across the left and right-sided SD patients and the FTD sub-categories. The boundaries of severe FTD and SD/bv-FTD were defined in terms of containing 25% of the cases with the most severe bilateral ATL and OFC atrophy, respectively. ATL anterior temporal lobe, OFC orbital frontal cortex, SD semantic dementia, bv-FTD behavioural-variant frontotemporal dementia. Source data are provided as a Source Data file.