Table 2.
Beta values of four ROI variables predicting task and factor scores.
| Left − right ATL volume | Left + right ATL volume | Left + right OFC volume | Left + right hippocampus volume | |
|---|---|---|---|---|
| Face semantics | ||||
| Oral picture naming | 0.35 (0.04–0.65)0.03 | 0.42 (0.04–0.81)0.03 | −0.06 (−0.50–0.39)0.81 | 0.06 (−0.38–0.49)0.80 |
| Word-picture verification | −0.11 (−0.40–0.19)0.47 | 0.34 (−0.04–0.71)0.08 | −0.12 (−0.56–0.69)0.60 | 0.27 (−0.16–0.69)0.22 |
| Picture associative matching | 0.07 (−0.23–0.37)0.64 | 0.26 (−0.12–0.64)0.19 | −0.01 (−0.46–0.43)0.95 | 0.29 (−0.14–0.72)0.19 |
| Object semantics | ||||
| Oral picture naming | 0.53 (0.26–0.79)0.0003 | 0.39 (0.05–0.72)0.03 | −0.36 (−0.75–0.03)0.07 | 0.33 (−0.05–0.71)0.10 |
| Word-picture verification | 0.27 (−0.03–0.57)0.08 | 0.44 (0.06–0.82)0.03 | −0.30 (−0.74–0.14)0.18 | 0.28 (−0.15–0.71)0.20 |
| Picture associative matching | −0.09 (−0.40–0.22)0.56 | 0.10 (−0.30–0.49)0.63 | −0.07 (−0.53–0.38)0.76 | 0.36 (−0.09–0.80)0.12 |
| Visual perception | ||||
| Object perception | 0.34 (0.00–0.69)0.05 | −0.07 (−0.50–0.36)0.75 | 0.16 (−0.34–0.66)0.52 | 0.03 (−0.45–0.52)0.89 |
| Face perception | −0.11 (−0.43–0.20)0.47 | −0.16 (−0.56–0.23)0.41 | 0.34 (−0.12–0.79)0.15 | 0.24 (−0.20–0.69)0.28 |
| NPI | ||||
| Agitation | −0.17 (−0.60–0.26)0.43 | −0.29 (−0.84–0.26)0.30 | 0.14 (−0.43–0.70)0.63 | 0.31 (−0.30–0.92)0.32 |
| Depression | −0.12 (−0.56–0.31)0.57 | −0.2 (−0.76–0.35)0.47 | −0.01 (−0.58–0.56)0.97 | −0.15 (−0.77–0.46)0.62 |
| Anxiety | 0.13 (−0.23–0.49)0.48 | −0.26 (−0.72–0.21)0.27 | 0.24 (−0.23–0.71)0.31 | −0.53 (−1.04–0.02)0.05 |
| Apathy | −0.01 (−0.38–0.35)0.95 | −0.28 (−0.75–0.19)0.24 | 0.79 (0.31–1.26)0.003 | −0.45 (−0.96–0.07)0.09 |
| Disinhibition | −0.25 (−0.68–0.18)0.25 | −0.14 (−0.69–0.41)0.61 | 0.09 (−0.46–0.65)0.73 | −0.24 (−0.85–0.36)0.42 |
| Irritability | −0.05 (−0.48–0.38)0.82 | 0.06 (−0.49–0.62)0.82 | 0.16 (−0.41–0.72)0.58 | −0.45 (−1.06–0.16)0.15 |
| PCA | ||||
| Factor 1: apathy | 0.23 (−0.09–0.55)0.17 | 0.03 (−0.38–0.44)0.88 | 0.39 (−0.08–0.87)0.11 | −0.37 (−0.84–0.09)0.12 |
| Factor 2: face | −0.19 (−0.46–0.08)0.16 | 0.12 (−0.22–0.46)0.49 | 0.16 (−0.23–0.56)0.42 | 0.29 (−0.10–0.68)0.15 |
| Factor 3: naming | 0.61 (0.37–0.86)0.00001 | 0.49 (0.18–0.81)0.003 | −0.34 (−0.70–0.03)0.07 | 0.10 (−0.26–0.46)0.57 |
| Factor 4: disinhibition | −0.13 (−0.47–0.20)0.44 | −0.02 (−0.45–0.40)0.91 | 0.11 (−0.38–0.61)0.65 | −0.04 (−0.52–0.44)0.87 |
| Factor 5: SD severity | 0.17 (−0.15–0.48)0.30 | −0.22 (−0.62–0.18)0.28 | 0.4 (−0.06–0.86)0.09 | 0.13 (−0.32–0.59)0.56 |
The task and factor scores were predicted by multiple linear regressions (n = 46, 44, 27 and 47 for word-picture verification, visual perception, NPI and others). The significance of beta values was tested by one sample t-tests compared with 0 (df = 45, 43, 26 and 46 for word-picture verification, visual perception, NPI and others). The numbers in parentheses are the 95% confidence intervals. The numbers in superscripts are the uncorrected p-values. Source data are provided as a Source data file.
ATL anterior temporal lobe, OFC orbital frontal cortex, NPI neuropsychiatric inventory, PCA principal component analysis.