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. 2020 May 22;10:8536. doi: 10.1038/s41598-020-65621-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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mTOR phosphorylation in HepG2 cells in response to treatment of the cells with metformin and AICAR. HepG2 cells were treated with 1 mM AICAR or 10 mM metformin for 24 h while culturing the cells in 5-mM glucose medium. (a) Western blot analysis depicting the phospho-mTOR (Ser-2448) in cell lysates from control and treated HepG2 cells. (b) Intensities of bands that correspond to the phospho-mTOR levels normalized to the respective total mTOR levels. Columns represent mean values of three independent experiments per group ± SD. **P < 0.01, ***P < 0.001, indicating a significant difference vs the untreated control.