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. 2020 May 22;10:8548. doi: 10.1038/s41598-020-65464-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between the optical and electrical signals of the pig heart. Optical signals were recorded by optical mapping in situ using di-4-ANBDQBS and electrical signals via electrography under artificial blood circulation. (a) Experimental recordings of optical action potentials obtained using di-4-ANBDQBS and electrograms during spontaneous rhythm and under applied stimulation with a period of 500 ms under the control condition and after the injection of a 50-mL bolus containing nifedipine (100 µmol/L). (b) The correlation between the duration of the optical signal at 60% repolarization (OAPD) and electrical signal (RT_peak) obtained under normal-physiological (n = 4, open red dots) or artificial blood perfusion, including with nifedipine (n = 4, closed red and blue dots, respectively). The presented data were obtained during spontaneous activity and a pacing period of 200–500 ms. The solid line indicates the theoretical linear dependence of OAPD and RT_peak, and the dashed lines indicate the boundaries of 5% deviation from the absolute values of the line points. (c) Effect of blebbistatin (bolus concentration 600 µmol/L) on the RT (blue points) and QRS (red points) intervals (n = 4). The pacing period was 500 ms. (d) Overlapped electrogram fragments recorded at different times after exposure to blebbistatin. The dashed lines mark the boundaries of the RT interval. EG, electrogram.