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. 2020 May 22;10:8546. doi: 10.1038/s41598-020-64881-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LFP power changes during the PREG and postpartum periods. LFP is shown for DIE2 day of the virgin EST cycle (n = 10), the first half of the PREG (PREG10 day, n = 6), the second half of the PREG (PREG20 day, n = 8), early PP (PP2 day, n = 9), middle PP (PP9 day) and late PP (PP16 day, n = 6). Panel A: delta power (1–4 Hz); panel B: theta power (4–10 Hz); panel C: alpha/sigma power (10–16 Hz); panel D: beta power (16–30 Hz); panel E: gamma power (30–48 Hz). Power values are expressed as percentage of normalized baseline (DIE2 day of the virgin EST cycle) values and summarized in 2-h long blocks. Red asterisks (*) indicate significant deviation during PREG10 day (left column) or PP2 day (right column), respectively, compared to DIE2 baseline. Blue asterisks (*) indicate significant deviation during PREG20 day (left column) or PP9 day (right column), respectively, compared to DIE2 baseline. Purple asterisks (*) indicate significant deviation during PP16 day (right column), respectively, compared to DIE2 baseline. Significance was tested with two-way ANOVA with time and treatment as factors, followed by Sidak’s multiple comparisons test. Significance levels: *,*,* - p < 0.05; **,**,** - p < 0.01; ***,***,*** - p < 0.001. Data are expressed as mean ± S.E.M.