Table 3.
Isolated genotypes of KLOTHO SNPs C1818T, G395A, and C370S and respective values of estimated glomerular filtration rate (eGFR).
| C1818T (rs564481) | eGFR | |
|---|---|---|
| mL/min/1.73 m² | P value | |
| CC | 58.0 (45.8–70.5) | 0.047 |
| CT | 58.2 (47.0–73.0) | |
| TT | 55.5 (41.5–64.2) | |
| Allele C | 58.1 (46.3–71.2) | 0.033 |
| Allele T | 57.8 (45.8–70.8) | 0.892 |
| G395A (rs1207568) | ||
| GG | 57.7 (45.9–70.5) | 0.468 |
| GA | 58.2 (44.7–71.6) | |
| AA | 52.7 (40.9–69.9) | |
| Allele G | 58.0 (45.9–70.6) | 0.461 |
| Allele A | 58.1 (44.5–71.3) | 0.814 |
| C370S (rs9527025) | ||
| CC | 57.3 (45.2–69.3) | 0.046 |
| CS | 60.1 (47.4–74.4) | |
| SS | 50.0 (50.0–50.0) | |
| Allele C | 57.9 (45.8–70.6) | 0.698 |
| Allele S | 60.1 (47.7–74.5) | 0.039 |
Continuous data are expressed as Median and Quartiles and analysed by Kruskal-Wallis Test adjusted by Bonferroni. For two groups, the analysis was performed by Mann-Whitney Test.