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. 2020 May 22;10:8532. doi: 10.1038/s41598-020-65640-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HRAS transformation leads to aberrations of nuclear membrane and accumulation of cytoplasmic chromatin in cancer cells. (A,B) TEM of nuclear-cytoplasmic boundary in IEC-18 and RAS-3 cells; disrupted nuclear envelope in RAS-3 cells. (C,D) Immunogold staining for histone; presence of cytoplasmic chromatin in RAS-3 cells (insets - high power 30,000X images of cytoplasmic chromatin deposits). (E,F) Immunogold - cytoplasmic staining of RAS-3 cells with anti-BrDU antibody indicates the presence of extranuclear newly synthesized DNA (insets - high power 18,500 X images of cytoplasmic BrdU positive material).