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. 2020 May 22;10:8532. doi: 10.1038/s41598-020-65640-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of micronuclei in endothelial cells exposed to EVs from oncogene-driven cancer cells. HUVEC cells were exposed for 7 days to EVs from cancer cells expressing mutant HRAS (carcinoma) or EGFRvIII (glioblastoma). (A) HUVEC micronuclei count upon treatment with control, IEC-18- or RAS-3-derived EVs. (B) HUVEC micronuclei count upon treatment with control, U373P- or U373vIII-derived EVs; **p < 0.01; ***p < 0.0001.