Table 2.

P40 serum analysis of Control and Nedd4-2^Ksp1.3 mice.

	Standard Na+		Low Na+
	Control (n = 6)	Nedd4-2Ksp1.3 (n = 5–6)	Control (n = 6–7)	Nedd4-2Ksp1.3 (n = 7)
K+ (mM)	4.17 ± 0.22	4.10 ± 0.20	4.23 ± 0.13	4.37 ± 0.22
Cl− (mM)	109.50 ± 0.22	108.30 ± 1.02	110.00 ± 0.68	110.00 ± 0.38
Ca2+ (mM)	2.46 ± 0.04	2.46 ± 0.04	2.45 ± 0.03	2.37 ± 0.04
Creatinine (uM)	17.17 ± 0.65	18.67 ± 1.23	16.29 ± 1.55	15.43 ± 1.13
Protein (g/L)	46.67 ± 0.49	48.00 ± 0.58**	45.17 ± 1.22	44.86 ± 0.34**
HCO3− (mM)	21.00 ± 0.73	19.67 ± 0.88	21.67 ± 0.76	21.57 ± 0.75
Anion gap (mM)	20.33 ± 0.71	23.20 ± 0.73*	19.17 ± 1.30	18.43 ± 1.13*
Albumin (g/L)	14.83 ± 0.31	15.00 ± 0.37	14.17 ± 0.48	13.86 ± 0.34
Globulin (g/L)	31.83 ± 0.48	33.00 ± 0.58*	31.00 ± 0.97	31.00 ± 0.31*

Data presented as mean ± SEM for number of mice (n) indicated in parentheses. Significance was determined using a Mann–Whitney test for non-normally distributed data

*P < 0.05, **P < 0.01 , comparing values in bold