Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 22;10:8580. doi: 10.1038/s41598-020-65352-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Late sirolimus treatment did not attenuate albuminuria and glomerulosclerosis in anti-Thy1.1 mice at day 31. (A) Albumin/creatinine ratio of phosal and sirolimus injected mice. No significant differences between the mice could be measured over time. Sirolimus treated mice n = 14, phosal treated mice n = 15. (B) The number of sclerotic glomeruli was not significant different between the sirolimus treated and control mice (day 31). At least 71 glomeruli per mouse were scored. Sirolimus treated mice n = 14, phosal treated mice n = 11. (C, D) Representative images of glomeruli stained with PAS of a (C) phosal treated mouse and a (D) sirolimus treated mouse. The histology between the phosal and sirolimus treated mice was comparable showing glomerulosclerosis (arrows), hyalinosis (asterisks) and PEC hyperplasia (arrowhead). Mean with SEM shown. ns P ≥ 0.05.