Table. 2.

Patients’ clinicopathological characteristics and their correlation with MLKL expression.

Characteristics	MLKL expression				p-MLKL expression			Tumor necrosis
	N = 191	Low	High	P*	Absent/focal	Extensive	P*	Absent/focal	Extensive	P*
		n = 96	n = 95		n = 130	n = 61		n = 100	n = 91
Gender
Male	129	68	61	0.328	83	46	0.112	61	68	0.043
Female	62	28	34		47	15		39	23
Age
<60	127	56	71	0.016	86	41	0.885	64	63	0.444
≥60	64	40	24		44	20		36	28
Tumor location
Tongue	111	58	53	0.227	70	41	0.671	55	56	0.292
Buccal	35	12	23		26	9		23	12
Floor of mouth	14	7	7		10	4		9	5
Gingiva	19	11	8		15	4		7	12
Palate	8	4	4		6	2		4	4
Oropharynx	3	3	0		1	0		1	0
Others	1	1	0		2	1		1	2
Tobacco
No	112	55	57	0.704	77	35	0.808	60	52	0.689
Yes	79	41	38		53	26		40	39
Alcohol
No	145	64	81	0.003	96	49	0.329	74	71	0.516
Yes	46	32	14		34	12		26	20
Areca-nut
No	173	88	85	0.604	116	57	0.353	90	83	0.775
Yes	18	8	10		14	4		10	8
T stage
Tis/1/2	122	58	65	0.248	77	46	0.029	62	61	0.468
3/4	67	38	30		53	15		38	30
N stage
N0	99	54	45	0.219	64	35	0.293	50	49	0.595
N+	92	42	50		66	26		50	42
Clinical stage
0/I/II	76	44	32	0.086	47	29	0.134	38	38	0.596
III/IV	115	52	63		83	32		62	53
Histologic grade
Gx/G0	99	46	53	0.276	65	34	0.459	48	51	0.266
G1/G2	92	50	42		65	27		52	40
Recurrence
No	125	62	63	0.632	82	43	0.530	65	60	0.096
Yes	14	6	8		8	6		4	10
Lymph node metastasis
No	119	60	59	0.271	84	35	<0.001	64	55	0.008
Yes	19	7	12		5	14		4	15
Tumor progression
No	108	55	53	0.462	77	31	0.004	60	48	0.013
Yes	30	13	17		13	17		9	21

^*Chi-square test, P < 0.05 was considered statistically significant.

Bold value indicates p value < 0.05.