Table 2.

Bio-function of MC mediators in adipose tissue biology

MC mediator	Bio-function in AT	Ref
Chymase	Promotes angiogenesis in AT	[24]
IFN-γ	Activation of AT-resident macrophages	[24]
MMP-9	Activation of AT-resident macrophages	[24]
Tryptase	Activates PAR2 through which upregulates the expression of inflammatory factors, such as TNF-α, IL-1β, and IL-6 in endothelial cells	[2]
MCP-6	Promotes the fibrosis in AT	[69]
IL-6	Induces the inflammation in AT	[8]
MCP-1	Induces the inflammation in AT	[8]
TNF-α	Pro-inflammatory cytokine involved in the pathogenesis of obesity, i.e., IR	[31]