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. 2020 Apr 22;469(1):41–51. doi: 10.1007/s11010-020-03726-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — SNHG16 targeted miR-10b-5p. a Using StarBase (https://starbase.sysu.edu.cn) to predict the downstream miRNA of SNHG16 and the result showed that miR-10b-5p was an important target. b The dual-luciferase activity assay was used to verify the targeting relationship between SNHG16 and miR-10b-5p. c Detection of miR-10b-5p expression by qPCR. d Construction of miR-10b-5p overexpression and low expression cell model. e Detection of SHNG16 expression by qPCR. NS, *, **, *** represents P > 0.05, P < 0.05, P < 0.01 and P < 0.001, respectively