Fig. 6.

SNHG16 regulated OGD-mediated neuronal damage via miR-10b-5p. A low expression cell model of SNHG16 was established, on the basis of low expression of miR-10b-5p by its specific inhibitor. a The cell proliferation ability was measured by the CCK8 method. b The LDH content in the medium was measured using an LDH kit. c Immunofluorescence staining was used to detect BNDF expression in HT22 cells. Scale bar = 100 µm. d, e The expression of BDNF in cells and culture medium was detected by qPCR and ELISA, respectively. f A diagrammatic sketch map of DEX induced neuroprotective effects on HT22 neurons under OGD treatment. **, *** represents P < 0.05, P < 0.01 and P < 0.001 compared with OGD group, ^## represents P < 0.01 compared with the sh-SNHG16 group