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. 2020 Mar 12;139(6):1025–1044. doi: 10.1007/s00401-020-02138-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Associations of p.P522R with CSF biomarkers of Alzheimer’s disease (AD). Black dots and arrows represent Cohen’s d estimates and 95% confidence interval, respectively. For Aβ_1-42, negative Cohen’s d estimates indicate more pathology. In the case of pTau₁₈₁ and tTau, positive Cohen’s d values represent more pathology. N(p.P522R) number of p.P522R carrier, n(wt) number of p.P522R non-carrier, Aβ_1-42 amyloid-beta 1-42, pTau₁₈₁ phosphorylated tau