Table 1.
Characteristics of MCI samples included in the analysis of the cognitive decline
| FACE | AgeCoDe | DCN | ADC | ADNI | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | |
| Sample size (n (% of total sample)) | 12 (1.1%) | 1080 (98.9%) | 26 (2.8%) | 901 (97.2%) | 9 (1.7%) | 520 (98.3%) | 4 (0.09%) | 427 (99.1%) | 10 (1.6%) | 606 (98.4%) | 61 (1.7%) | 3534 (98.3%) |
| Age (m (SD)) | 77.56 (5.02) | 76.64 (6.91) | 81.15 (4.58) | 82.31 (4.72) | 65.78 (8.63) | 66.68 (8.35) | 65.63 (4.47) | 66.99 (7.40) | 72.61 (7.55) | 73.32 (7.50) | 75.76 (8.34) | 74.89 (8.92) |
| Female gender (n (%)) | 10 (83.3%) | 692 (64.1%) | 18 (69.2%) | 587 (65.1%) | 3 (33.3%) | 224 (43.1%) | 1 (25.0%) | 144 (33.7%) | 6 (60.0%) | 233 (38.4%) | 38 (62.3%) | 1880 (53.2%) |
| High education (n (%)) | 2 (16.7%) | 245 (22.7%) | 18 (69.2%) | 509 (56.5%) | 5 (55.6%) | 231 (44.4%) | 2 (50.0%) | 293 (68.6%) | 8 (80.0%) | 520 (85.8%) | 35 (57.4%) | 1798 (50.9%) |
| APOE-ε4 carrier (n (%)) | 4 (33.3%) | 364 (33.7%) | 8 (30.8%) | 223 (24.8%) | 6 (66.7%) | 191 (36.7%) | 2 (50.0%) | 223 (52.2%) | 3 (30.0%) | 298 (49.1%) | 23 (37.7%) | 1299 (36.8%) |
| MMSE at baseline (m (SD)) | 25.58 (2.81) | 25.49 (2.90) | 25.35 (2.43) | 26.19 (2.12) | 27.56 (1.88) | 27.21 (2.07) | 25.50 (3.11) | 26.74 (2.18) | 27.60 (1.51) | 27.66 (1.76) | 26.10 (2.49) | 26.45 (2.47) |
| Mean observation time (m (SD), in years) | 5.07 (3.39) | 5.06 (3.08) | 5.83 (4.27) | 4.16 (3.53) | 2.51 (0.83) | 1.83 (1.12) | 0.84 (1.44) | 2.44 (2.04) | 5.73 (2.07) | 4.12 (2.46) | 4.85 (3.60) | 3.88 (3.02) |
High education was operationalized as participation in secondary education
MMSE mini-mental state examination, n(%) number of individuals and percent within group, m mean, SD standard deviation