Table 2.
Characteristics of population-based samples included in the analysis of the cognitive decline
| AgeCoDe | 3 City study | LASA | ||||
|---|---|---|---|---|---|---|
| p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | |
| Sample size (n (% of total sample)) | 49 (2.5%) | 1918 (97.5%) | 127 (2.2%) | 5760 (97.8%) | 56 (2.5%) | 2187 (97.5%) |
| Age (m (SD)) | 79.71 (3.64) | 79.56 (3.51) | 73.98 (5.22) | 74.22 (5.46) | 63.47 (6.39) | 64.79 (7.63) |
| Female gender (n (%)) | 32 (65.3%) | 1245 (64.9%) | 81 (63.8%) | 349 (60.6%) | 34 (60.7%) | 1159 (53.0%) |
| High education (n (%)) | 23 (46.9%) | 848 (44.2%) | 49 (38.6%) | 3030 (52.6%) | 45 (80.4%) | 1619 (74.0%) |
| APOE-ε4 carrier (n (%)) | 10 (25.6%) | 410 (21.4%) | 33 (26.0%) | 1188 (20.7%) | 18 (29.6%) | 638 (28.8%) |
| MMSE at baseline (m (SD)) | 26.88 (2.34) | 27.41 (1.95) | 27.34 (1.96) | 27.37 (1.92) | 27.64 (2.36) | 27.88 (2.01) |
| Mean observation time (m (SD), in years) | 6.05 (4.08) | 6.21 (4.03) | 5.40 (2.28) | 5.34 (2.36) | 11.72 (7.62) | 10.73 (7.05) |
High education was operationalized as participation in secondary education
MMSE mini-mental state examination, n(%) number of individuals and percent within group, m mean, SD standard deviation