Table 3.
Characteristics of samples included in the analysis of CSF AD-biomarkers
| UHB | DCN | ADC | ADNI | Total | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | p.P522R carrier | p.P522R non-carrier | |
| Sample size (n (% of total sample)) | 1 (1.1%) | 86 (98.9%) | 8 (2.3%) | 334 (97.7%) | 2 (0.5%) | 379 (99.5%) | 7 (1.6%) | 444 (98.4%) | 18 (1.4%) | 1243 (98.6%) |
| Age (m (SD)) | 63.00 (0.00) | 66.83 (8.58) | 67.88 (10.11) | 66.55 (8.17) | 64.65 (3.18) | 67.03 (7.72) | 74.16 (5.36) | 72.75 (7.54) | 69.69 (8.26) | 68.93 (8.34) |
| Male gender (n (%)) | 1 (100%) | 53 (61.6%) | 6 (75.0%) | 191 (57.2%) | 2 (100%) | 251 (66.2%) | 2 (28.6%) | 272 (61.3%) | 11 (61.7%) | 767 (61.7%) |
| APOE-ε4 carrier (n (%)) | 0 (0.0%) | 41 (47.7%) | 5 (62.5%) | 138 (41.3%) | 2 (100%) | 194 (51.2%) | 3 (42.9%) | 211 (47.7%) | 10 (55.6%) | 584 (47.0%) |
| CSF Aβ1-42 levels (m (SD) in pg/mL)a | 354.86 (0.00) | 736.09 (337.80) | 615.75 (308.64) | 759.47 (344.36) | 719.00 (172.08) | 732.18 (345.58) | 711.34 (204.54) | 717.03 (326.14) | 649.90 (337.89) | 734.37 (252.03) |
| CSF pTau181 levels (m (SD) in pg/mL)b | 52.51 (0.00) | 67.42 (34.19) | 40.58 (9.44) | 65.58 (34.70) | 72.46 (28.12) | 66.02 (34.75) | 56.52 (24.09) | 71.84 (37.70) | 50.98 (20.15) | 68.08 (35.86) |
| CSF total tau levels (m (SD) in pg/mL)c | 227.21 (0.00) | 464.46 (335.86) | 269.88 (80.76) | 452.35 (415.61) | 548.35 (281.39) | 420.87 (225.87) | 326.83 (164.79) | 436.35 (257.94) | 320.60 (157.39) | 437.03 (304.20) |
| Pathological Aβ1-42 CSF levels (n (%))a | 1 (100%) | 26 (30.2%) | 5 (62.5%) | 132 (39.5%) | 1 (50.0%) | 194 (51.2%) | 5 (71.4%) | 290 (65.3%) | 12 (66.7%) | 642 (51.6%) |
| Pathological pTau181 CSF levels (n (%))b | 0 (0.0%) | 42 (48.8%) | 0 (0.0%) | 148 (44.3%) | 2 (100%) | 232 (61.2%) | 5 (71.4%) | 325 (73.1%) | 7 (38.9%) | 747 (60.1%) |
| Pathological total tau CSF levels (n (%))c | 0 (0.0%) | 27 (31.4%) | 3 (37.5%) | 198 (59.3%) | 2 (100%) | 197 (52.0%) | 2 (28.6%) | 161 (36.3%) | 7 (38.9%) | 583 (46.9%) |
Aβ1-42 amyloid-beta 1-42, pTau181 phosphorylated tau, CSF cerebrospinal fluid, n(%) number of individuals and percent within group, m mean, SD standard deviation
aSample size n = 1259
bSample size n = 1255
cSample size n = 1215