Table 5.

Studies assessing alternative measures of ovarian reserve

First author, year, country	Population	Did enrollment criteria allow women with a personal history of cancer	Outcome	Findings	Adjusted for
Lin, USA, 2017	Age: 24–40 years Cases: 13 BRCA1+, 5 BRCA2+ women undergoing oophorectomy (no personal history of breast cancer) Controls: 12 organ donor cadaver ovaries	No	Primordial follicle density, and percentage of DNA double-strand break (DSB)–positive primordial follicle oocytes	Women with BRCA mutations have diminished ovarian reserve as well as accelerated primordial follicle loss and oocyte DNA damage BRCA1 and BRCA2 mutations were associated with lower primordial follicle density compared with controls BRCA1 mutations were associated with higher DNA DSBs than controls The rates of follicle decline and DNA DSB accumulation appeared to be accelerated, particularly in primordial follicle oocytes of BRCA mutation carriers over age 30 years	Age
Pavone, USA, 2014	Age: 18–51 Cases: 35 BRCA1/2+ or with a strong family history of breast and/or ovarian cancer undergoing oophorectomy Controls: 99 = (20 with ovarian cancer) + (69 with benign conditions) + (10 pregnant or immediately postpartum)	Yes	Follicle count	Patients undergoing risk-reducing surgery had significantly decreased follicle count compared with physiologic control Patients with cancer had significantly decreased counts compared with all other groups There were no differences within the benign cohort	Age